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《International Journal of Laboratory Medicine》 2008-02
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Distribution and antibiotic resistance analysis of Escherichia coli in tumor patients

GUO Feng-li ZHOU You-quan,GU Ying.Department of Clinical Laboratory,Yunnan Provincial Tumor Hospital, Kunming 650118,China  
Objective To investigate the distribution and antibiotic resistance of Escherichia coli in tumor patients and to guide an appropriate use of antibiotics in clinical therapy.Methods Conven tional method or API system was applied to identifying Eseherichia coli of infected species collected from tumor patients in our hospital from 2004 to 2005.Drug susceptibility test was performed with KB method,and extended spectrum beta lactamases(ESBLS)were confirmed by double disk diffusion method.Statistical analysis for strain source,distribution and drug resistance results was carried out by WHOVET5.3 and SPSS11.0 software.Results A total of 178 Eseherichia coli strains were isolated. The main positive species were urine,sputum,vaginal secretions and wound discharge collected mainly from patients with uterine cervix cancer,lung cancer,intestinal cancer and endometrial cancer. The detected rate of ESBLs-producing E.coli was 57.87%.The resistant rate of Escherichia coli to imipenem was zero.ESBLs-producing and non ESBLs-produeing Escherichia coli strains were both sensitive to imipenem,piperacillin/tazobactam,amikacin and furadantin.The resistant rate of ESBLs-producing strains were much higher than that of non-ESBILs-producing ones,especially to the third cephalosporin(P0.01).Conclusion E.coli is the chief pothogenic bacterium in our hospital.It should be the first consideration when urinary infection in patients with uterine cervix cancer,vaginal cancer,ovarian cancer and lung cancer,postoperative wound infection in patients with intestinal cancer or respiratory infection in patients with lung cancer occurs.Antibacterial agents should be chosen rationally according to in vitro drug susceptibility test and identification results of ESBLs-producing bacteria, while the surveillance of antimicrobial resistance of Eseherichia coli should be paid attention to.
【CateGory Index】: R446.5
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