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The systematic evaluation of SELDI-TOF-MS in diagnosis of ovarian cancer

LIANG Shuang-hua,WANG Kai-zhen (1.First People's Hospital of Hengyang City,Hunan 421000,China; 2.The First Affiliated Hospital of Luzhou medical college,Sichuan 646000,China)  
Objective To assess overall diagnostic value of SELDI-TOF-MS in early breast cancer.Methods To search and identify the relevent articals in English and Chinese from Jan.1999 to Dec.2007 on Medline,WeiPu full-text data base and WanFang data base,and the literatures have been integrated to review the quality rating,and the heterology examination and the meta analysis were conducted.While the summary receiver operating characteristic curve(SROC),pooled sensitivity,specificity and odds rate were calculated by SPSS13.0 software.Results 22 pertinent literatures can be indexed as a whole,of which 8 articles including 739 samples entered this Meta analysis.The pooled sensitivity,specificity and odds rate were 91.4%,99.5%and 30.88 respectively. The area under the SROC curve was 0.822 5.Conclusion SELDI-TOF-MS is valuable in diagnosis of ovarian cancer.
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