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Exploration of the effects of platelet activation on the patients with malignant tumor and their prognoses

ZHANG Ai-hua,LIU Wen-li,WEI Wen-ning,et al. (Zhuhai People' s Hospital,Zhuhai Guangdong 519000 China)  
Objective To study the effects of platelet activation and injury of endothelial cell on the patients with malignant tumor and the prognoses.Methods Radio-immunity and ELISA were employed to detect the TXB_2,DH-TXB_2,TSP,β-TG,GMP- 140,CGMP and FN of 223 cases of patients with malignant tumor and 80 cases of normal,and healthy control persons.Results 1) Except of the TSP,GMP-140 the hepatic cancer group,the levels of TXB_2,DH-TXB_2,TSP,β-TG,GMP-140 and CGMP increased in the lung cancer group,the intestinal cancer group and hepatic cancer group,while FN decreased in the intestinal cancer and lung cancer group.2) CGMP was positively related to TXB_2,DH-TXB_2,TSP,β-TG,GMP-140 in malignant tumor group.3)TSP increased and FN decreased in the infection group and the without-metastasis group while the TXB_2,DH-TXB_2,TSP,β-TG,GMP- 140,CGMP increased but FN decreased.DH-TXB_2,TSP,β-TG,GMP-140,and CGMP decreased while FN increased after operation. Conclusion 1)Activations of platelet existed in the patients with malignant tumor,and the platelet activation is severe in lung cancer and intestinal cancer,but light in hepatic cancer.2) Activations of platelet affect the metastasis and prognosis of malignant tumor.
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