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Research for difference and sense of B cell epitope human hepatitis virus B genotype-B and genotype-C

WANG Guo-qiang~1,NIU Ju-xia~2,JIA An-kui~1. 1.Department of Clinical Laboratory of the first Affiliated Hospital of XinXiang Medical University Weihui,Henan 453100,China;2.Xinxiang Infectious Disease Hospital Henan 453000,China  
Objective To study the difference and sense of B cell epitope of S protein HBV genotype B and genotype C. Methods Search for amino acid sequence of S protein of HBV genotype C and genotype B from GenBank for international network and forecast B cell epitope of S protein of HBV genotype band genotype C by DNAStar Bio-software and by Kolaskear-tongaonaka method through the international network.Results There are five B cell epitopes about amino acid of S protein of HBV genotype B and three HBV genotype C and antigenic index(1.0798) of amino acid of S protein of HBV genotype B is higher than that of HBV genotype C(1.0729).Conclusion Human hepatitis B genotype C is easier to develop chronic hepatitis than that of Human hepatitis B genotype B,It may be related with the fact that there are fewer B cell epitopes and lower antigenic index about S protein in human hepatitis B genotype C than that in human hepatitis B genotype B.
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