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The analysis of AMA-M2 subtype and karyotype in consecutive patients with postive anti-mitochondria antibodies

YANG Guo-xiang~1,LI Li-jun~2,DONG Xiao-juan~2,et al. (1.China Medical Science Institute Laboratory of PUMMC & CAMS of Bejing Union Hospital Bejing 100032,China; 2.Department of Clinical Laboratory of Iner Mongonia Hospital 010017,China)  
Objective To study the concentration distribution of AMA-M2 and explore the concomitant karyotype in patients with different titers of anti-mitochondria antibodies.Methods The autoantibodies in specimen were measured by indirect immuno-fluorescence assay(IIF),AMA-M2 subtype in 502 specimens with positive anti-mitochondria antibodies was measured by ELISA, and the AMA-M2 and ANA karyotype in 71 patients with primary biliary cirrhosis were analyzed.Results The positive rates of AMA-M2 subtype is 76.1%in 4258 consecutive specimen including 502 specimens with positive anti-mitochondria antibodies.Of the 71 patients with PBC,95.8%of them have positive anti-mitochondria antibodies with titers above 1:160,90.1%above 1:320, 73.2%above 1:640.95.8%patients have positive AMA-M2 subtype including 67.6%above 200 RU/ML,84.5%above 100 RU/ML.56.3%patients have positive ANA.Conclusion The positive of AMA and AMA-M2 in patients with primary biliary cirrhosis appears high concentration.High titer of AMA,AMA-M2 and specific karyotype of ANA contributes to the diagnosis of PBC.
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