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The application of HBV-LP in diagnosis and prognosis of the patient with HBV

GAO Hai-yan,ZHANG Hui-ling,YANG Yang,et al. (Department of Clinical Laboratory of Liangzhou Hospital,Wuwei,Gansu 733000,China)  
Objective To investigate the relationship between HBV-LP and the copy of HBV,and to evaluate the application of HBV-LP in diagnosis and prognosis of the patients with HBV.Methods The HBV-LP HBVM and HBV DNA levels in serum collected from 200 cases of HBsAg positve patients,and HBVM HBV DNA levels in serum colleced from 60 HBV patients who had been treated by Lamivudine for half a year,were detected by ELISA FQ-PCR,and the results of HBV DNA were compared.Results The pick-out positive rate of HBV-LP(P0.05)and HBV DNA(P0.05)had a statistically significant difference compared with HbeAg.The pick-out positive rate of HBV-LP had no statistically significant difference with that of HBV DNA serum levels of HBV-LP(P0.05).The 60 HBV patients under anti-virus treatment showed no statistically significant difference with HBV DNA.Conclusion HBV-LP levels in serum can accurately indicate the HBV infection and its copy in vivo,and detecting HBV-LP dynamically could help to improve the treatment of the patients with HBV.
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