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Study on chemokines and its receptors in peripheral blood from patients with breast cancer

GUO Man-ying,CHEN Yang,WANG Dong,et al. (Department of Clinical Laboratory,the 98th Hospital of PLA Huzhou Zhejiang 313000,China)  
Objective To study the role of serum chemokines and its receptors in the pathogenesis of breast cancer.Methods Serum levels of monocyte chemotactic protein 1(MCP-1) regulation on activation normal T-cell expression and secretion(RANTES), interleukin 8(IL-8),and the stromal cell derived from factor-1(SDF-1) were determined by enzyme-linked immunosorbent assay (ELISA)in 30 patients with breast cancer and 30 normal controls.Meanwhile,chemokine receptors,CCR2,CCR5,CXCR1 and CXCR4 on peripheral blood CD3~+-lymphocytes from 20 patients and 20 normal controls were analyzed by flow cytometry with two-color immunofluorescent stains.Results Serum levels of SDF-1 and RANTES were significantly higher in patients than those in controls(P0.01).There was no significant difference in expressions of CCR2,CCR5,CXCR1 and CXCR4 on peripheral blood CD3~+ T-lymphocytes between patients and controls.Conclusion The increase of levels of SDF-1 and RANTES may play an important role in the occurrence and development of breast cancer.
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