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Analysis of food allergens specific IgE,IgG in patients with chronic urticaria

Bi Chao,Liang Yanhua,Li Xiaodong,Zhang Li,Song Weizhong,Wu Debiao (Department of Clinical Laboratory,Guangzhou Institute of Dermatology,Guangzhou,Guangdong 510095,China)  
Objective To explore the relationship of food allergens specific IgE with IgG and chronic urticaria,and to provide evidence for the prevention and treatment of food allergy.Methods 9 kinds of specific IgE and 14 kinds of specific IgG were detected in serum of 134 cases with chronic urticaria and 30 cases of healthy controls by Western blot and ELISA.Results The positive rates of food allergens had no difference between male and female.The overall positive rates of specific IgE was 73.1%,among which the top three were shrimps and crabs(35.1%),milk(32.1%) and cashew(23.1%) and the positive rates of shrimps,crabs and cashew increased with age,but that of milk decreased.The overall positive rates of specific IgG was 82.1%,among with the top three were eggs(40.3%),milk(38.1%) and crabs(38.1%),and the positive rates of shrimp,crab and beef increased with age,but those of milk and eggs decreased.There were fine coincidence between shrimps and crabs,milk and beef specific IgE and IgG.Conclusion Detection of specific allergens could be an important means of prevention and treatment of food allergy.
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