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Changes of blood 1,25-dihydroxyvitamin D_3 level in patients with chronic kidney disease

Qiao Weizhou,Xu Weijia,Wang Qing,Xue Banglu,Liu Yi (Clinical Laboratory,Dalian Municipal Central Hospital,Dalian 116033,China)  
Objective To understand the relationship between blood 1,25-dihydroxyvitamin D3 (vitamin D3) level and renal impairment in patients with chronic kidney disease (CKD).Methods 150 cases of healthy controls(control group) and 101 cases of CKD patients were enrolled and blood level of vitamin D3,parathyroid hormone (PTH),calcium,phosphorus,creatinine,albumin and blood urea nitrogen (BUN) were determined.Meanwhile,glomerular filtration rate (GFR) was calculated.Results Compared with control group,the blood vitamin D3 level of CKD patients at stages 4-5,albumin level of CKD patients at all stages and calcium level of only patients at stage 5 were significantly decreased (P0.05),but blood phosphorus level of patients at stage 4-5 and the PTH,creatinine and BUN levels of CKD patients at stages 3-5 were increased (P0.05).Significantly negative correlations between blood vitamin D3 level and blood PTH,creatinine and BUN levels and positive correlations between blood vitamin D3 level and blood calcium,albumin and GFR level were confirmed (P0.05).Conclusion CKD patients at stages 4-5 might be deficient with vitamin D3,indicating that there could be obvious abnormality of blood vitamin D3 level in CDK patients,only when the renal impairment was severe.Meanwhile,the present study also shows that there are some relationships between blood vitamin D3 level and other biochemical indicators of renal function in CKD patients.
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