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Analysis of correlation between effective hepatic blood flow and liver function indexes and its significance for the assessment of liver reserve function

Li Kun1,Wang Chao1,Zhang Yujun2,Zheng Ping2,Wang Huaizhi2 (1.Basic Laboratory for Medical Center of People′s Liberation Army of China,Chengdu Military General Hospital, Chengdu 610083,China;2.Hepatobiliary Surgery Institute of People′s Liberation Army of China,Southwest Hospital, Third Military Medical University,Chongqing 400038,China)  
Objective To investigate the relationship between effective hepatic blood flow(EHBF) and total bilirubin(TBIL),total bile acids(TBA),albumin(ALB) and prealbumin(PA),and its clinical significance for the assessment of liver reserve function.Methods Both indocyanine green 15 minutes retention rate(ICGR15) and EHBF were detected by pulse dye densitometry(PDD) in 288 patients with hepatocellular carcinoma and the correlation between IGGR15,EHBF and other liver function indexes were analyzed.Results EHBF decreased significantly as ICGR15 increasing.When ICGR15 was higher than 40%,EHBF was only 26.15% of that when ICGR15 was less than 10%.EHBF was significantly negatively correlated with ICGR15 (EHBF=1.259-0.270 ICGR15,r=-0.716,P0.001).As ICGR15 increased,ALB and PA decreased significantly,whereas TBIL,TBA and PT increased significantly.The liver function indexes were significantly correlated with ICGR15 and EHBF.Conclusion PDD assay could be noninvasive,real-time and convenient.EHBF might be helpful for surgeons to judge the mode and range of operation.Serum TBA,PA,ALB,TBIL and PT could be helpful for the assessment of liver reserve function and prognosis of patients with hepatocellular carcinoma.
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