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Dynamic analysis of T lymphocyte subsets in children with infectious mononucleosis

Cao Youde,Nie Shengdan,Deng Zhonghua,Long Lu (Department of Clinical Laboratory,Hu′nan People′s Hospital,Changsha,Hu′nan 410005,China)  
Objective To investigate the immunity function in children with infectious mononucleosis(IM),caused by epstein-barr virus(EBV) infection,by measuring T lymphocyte subsets in peripheral blood .Methods Flow cytometry (FCM) technique was applied to quantitatively analyze CD3+,CD4+,CD8+ and CD4+/CD8+ T lymphocyte subsets in peripheral blood of 30 case of child patients with IM at acute or convalescent stage and 24 cases of healthy controls.Results Compared with control group,positive rates of CD3+ and CD8+ T lymphocyte subsets in child patients at acute phase were obviously increased(P0.05),while CD4+ and CD4+/CD8+ were significantly decreased(P0.05).Compared with child patients at acute stage,positive rates of CD3+ and CD8+ in child patients at convalescent stage were obviously decreased(P0.05),which were still higher than control group(P0.05),but CD4+ and CD4+/CD8+ were significantly increased(P0.05),which were still lower than control group(P0.05).Conclusion The variation of immune function,characterized by obvious abnormality of T lymphocyte subsets in peripheral blood at acute stage,could be one of the main causes of IM in child patients.There is vital clinical significance to monitor the immunity function in for the prognosis of IM in child patients,
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