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Preliminary study on Th17 cells in peripheral blood of child patients with infectious mononucleosis

Song Jianxin,Zhu Hongyan,Dian Zijin (Department of Laboratory,the First People′s Hospital of Yunnan,Kunming 650032,China)  
Objective To study the changes and clinic significance of Th17 cells of IL-17,IL-6 in peripheral blood of child patients with infectious mononucleosis(IM).Methods CD4+ T lymphocytes were negatively selected from peripheral blood mononuclear cells(PBMC),separated from peripheral blood of child patients with IM and healthy controls,and were analyzed for the expression level of IL-17 and IL-16 by flow cytometry,after being treated with PMA/Ion,fixation and intra-cellular dyeing by membrane penetration.Results The expression levels of IL-17 and IL-6 in child patients with IM at acute stage were higher than at convalescence stage(P0.01),and all of them were higher healthy controls(P0.01).Conclusion There could be abnormal increase of Th17 cells and related cytokines in child patients with IM,both of which might be correlated with pathogenetic condition and could be performed as indexes for the estimation of immune function and prognosis of child patients with IM.
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