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Correlation study about lipoprotein associated lipoprotein phospholipase A2 and acute ischemic strokes

Jin Yan1,Zhang Chunhe1,Liu Jingxia2,Xiao Guohui3 (1.Department of Laboratory,People′s Hospital of Cangzhou,Cangzhou,Hebei 061000,China; 2.Department of Laboratory,Third Hospital of Cangzhou,Cangzhou,Hebei 061001,China; 3.Department of Laboratory,Nanpi County Hospital,Cangzhou,Hebei 061500,China)  
Objective To explore the relationship between plasma level of lipoprotein associated phospholipase A2(Lp-PLA2) and acute cerebral arterial thrombosis(ACAT) to provide the basis for clinical diagnosis and therapy of disease.Methods Enzyme-linked immunosorbent assay(ELISA) was performed for the detection of plasma level of Lp-PLA2 in 151 cases of patients with ACAT (experimental group) and 100 cases of healthy controls(control group).Results (1) Plasma level of Lp-PLA2 in experimental group were higher than control group(t=21.307,P=0.000).There were positive correlations between plasma Lp-PLA2 level and the risks factors of ACAT.(2)There was no difference of plasma Lp-PLA2 level between patients with different types of ACAT (P0.05).Conclusion Lp-PLA2 could be a risk marker for ACAT and detection of its plasma level might be helpful for guiding prevention strategies and providing basis for clinical therapy.
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