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Changes and clinical value of heart-type fatty acid binding protein in patients with acute hypertensive cerebral hemorrhage

Yang Wendong (Department of Clinical Laboratory,The Second People′s Hospital of Lijin,Dongying,Shandong 257447,China)  
Objective To understand the clinical value of heart-type fatty acid binding protein (h-FABP) in patients with acute hypertensive cerebral hemorrhage(AHCE) through the variation analysis of its serum level.Methods Serum level of h-FABP was determined by enzyme-linked immunosorbent one-step quantitative detection,cardiac troponin I(cTnI) was detected by solid-phase enzyme-linked immunosorbent assay (ELISA) and isoenzyme MB of creatine kinase(CK-MB) was assayed by immunosuppression assay.Results The h-FABP level in(AHCE) group was significantly higher than healthy control group(P0.01) and that in AHCE patients with massive haemorrhage and unconsciousness was significantly higher than in patients with small heamorrhage and consciousness.The positive rate of h-FABP was significantly higher than cTnI,CK-MB and electrocardiogram(P0.01).The mortality rate in patients,with abnormality of serum level of h-FABP,cTnI and CK-MB and ECG,was higher than patients without the abnormality,mentioned above (P0.01).The sensitivity and negative predictive value of serum h-FABP for the prediction of fatality were high,but with low specificity and accuracy,although the specificity and accuracy of ECG were relatively higher,with 64.5% and 69.1% respectively.Conclusion Quantitative detection of serum h-FABP could be an objective indicator for the judgement of disease condition and the evaluation of accidental risk of AHCE,with more clinical application value,when being combined with ECG inspect.
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