Full-Text Search:
Home|About CNKI|User Service|中文
Add to Favorite Get Latest Update

Clinical application value of lipoprotein(a) in patients with type 2 diabetic nephropathy

Zhang Jingxia,Zhuang Mintuo,Wu Lijuan (Department of Clinical Laboratory,The Orthopedics and Traumatology Hospital of Xiashan,Zhanjiang,Guangdong 524003,China)  
Objective To investigate the clinical value of 24 h-UAER and Lp(a) for the early diagnosis of type 2 diabetic nephropathy.Methods 329 cases of patients with diabetes mellitus(DM) were divided into 4 groups according to the positive degree of urine protein test,and 24 h-UAER and Lp(a) were measured for all groups by immune turbidimetry.The two quantitative indexes were analyzed for correlation and compared with healthy controls (control group).Results Variance analysis indicated that the 24 h-UAER and Lp(a) levels of those group were different(P0.01) and those in all DM groups were higher than control group.According to q test,there was no difference of Lp(a) level between urinary protein negative group and control group (P0.05),but the difference of 24 h-UAER was statistically significant(P0.01).In urinary protein positive group,Lp (a) and 24 h-UAER were positively correlated with fine correlativity.The detection rate of Lp(a),higher than normal upper limit,of urinary protein negative group and urinary protein±- + group were 11.4% and 18.7%,without significant difference with control group(P0.05),of urinary protein + + group and + + + and upper group were 55.0% and 80.2%,respectively,with significant difference with control group(P0.05,P0.01).Conclusion Lp(a) could be used as a experimental index for the diagnosis of type 2 diabetic kidney injury,with clinical application value for the diagnosis,prevention and therapy of diabetic nephropathy.
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©CNKI All Rights Reserved