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《International Journal of Laboratory Medicine》 2015-01
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Association analysis of 5509-5511delCAA polymorphism in Tim-1 exon4 with rheumatoid arthritis in Han population of Yunnan province

Cao Xianghong;Peng Chuanmei;Gao Hui;Fu Xiaoye;Dong Yulin;Wang Yang;Department of Medical Laboratory,Affiliated Yan′an Hospital of Kunming Medical University;  
Objective To analyze the association between the polymorphism of 5509-5511 delCAA in exon4 of Tim-1gene and the susceptibility to rheumatoid arthritis(RA)in a group of Han population from Yunnan province.Methods The PCR-DNA sequencing analysis was used to detect the polymorphism of 5509-5511 delCAA in exon4 of Tim-1gene in 196 RA Han nationality patients and 190 individuals of healthy physical examination(control).The ELISA method and indirect immunofluorescence assay was adopted to detect the three related aotuantibodies of RA,including the rheumatoid factors(RF)and the anti-cyclic citrullinated peptide(Anti-CCP)and the anti-keratin antibodies(AKA).Results There were statistically significant differences in genotype and allele frequency of 5509-5511 delCAA between the RA group and the control group(P0.05);the positive rate of RF and the antiCCP between different genotypes of 5509-5511 delCAA in the RA group had no statistically significant differences(P0.05),but the positive rate of AKA between different genotypes of 5509-5511 delCAA in the RA group had statistically significant differences(P0.05).Conclusion The 5509-5511 delCAA site of Tim-1exon4 has the polymorphic variation,the 5509-5511 delCAA genotype maybe related with the genetic susceptibility to RA in Han population of Yunnan province,the different genotypes does not affect the expression of RF and the anti-CCP,but affects the expression of AKA.
【Fund】: 云南省教育厅科学研究基金(2011C094);; 云南省应用基础研究计划自筹项目(2013FZ237)
【CateGory Index】: R446.6;R440
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