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《International Journal of Laboratory Medicine》 2015-01
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Analysis of genotype spectrum in condyloma acuminate tissues HPV infection of female anus and anal canal

Zhang Jinhao;Cai Weimin;Geng Jianxiang;Xia Lin;Wang Hongjing;Wu Kunlan;Shao Xin;Mei Jing;Zhao Xue;National Anal and Colorectal Medical Center of Chinese Medicine,Third Affiliated Hospital of Nanjing Traditional Chinese Medical University;Department of Pathology,Third Affiliated Hospital of Nanjing Traditional Chinese Medical University/Jiangsu Provincial HPV Collaboration Group;  
Objective To study the genotypes of human papillomavirus(HPV)infection in female anus and anal canal condyloma acuminata(CA)tissues and their clinical significance.Methods 23 kinds of HPV-DNA were extracted from the paraffin-embedded anus and anal canal tissue samples in 140 cases of female CA and detected by using PCR combined with the gene-chips technique.Furthermore the related clinical pathological data of the patients were analyzed.Results Among 140 female anus and anal canal CA tissue samples,103 cases were HPV positive and the total HPV infection rate was 73.57%(103/140).Among them,68 cases were single type HPV infection,the positive detection rate was 48.57%(68/140)and 35 cases were multiple types HPV infection,the positive detection rate was 25.00%(35/140).In single type HPV infection,34 cases were HPV11 and the positive detection rate was 24.29%(34/140),HPV11 was the main infection type,followed by HPV 6in 27 cases,its positive detection rate was19.29%(27/140).In the multiple types HPV infection,13 cases were HPV 6+11,accounting for 37.14%(13/35)of multiple types infection,followed by HPV11+18in 3cases and HPV 6+11+16in 3cases,each accounting for 8.57%(3/35)of the multiple types infection.Conclusion HPV 6,11,6+11,11+18and 6+11+16are the main infection genotypes in female anus and anal canal CA.PCR combined with the gene-chips technique is a diagnostic method more suitable for clinical development of HPV genotyping detection,which has high sensitivity and good specificity and is especially suitable for the molecular epidemiology study of HPV infection.
【Fund】: 江苏省南京市卫生局中医专项资助项目(2009-92)
【CateGory Index】: R752.53
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