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《International Journal of Laboratory Medicine》 2015-01
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Effects of pidotimod on Treg/Th17 cell immunity in children with Henoch-Schonlein purpura

Liu Caixia;Luo Huili;Yao Yuan;Li Xinchao;Department of Pediatrics,Affiliated Taihe Hospital,Hubei Medical College;  
Objective To observe and analyze the effects of pidotimod on the immunity of Treg/Th17 cells in the children with Henoch-Schonlein purpura(HSP).Methods 60 cases of HSP were selected and randomly divided into the pidotimod treatment group and the conventional treatment group,30 cases in each group.30 healthy children were selected as the control group.The conventional treatment group was given the routine therapy,while the pidotimod treatment group was added with oral pidotimod dispersible tablets on the basis of the routine therapy.The ratios of Treg cell subsets and Th17 cell subsets,the plasma expression levels of interleukin-17(IL-17),tumor necrosis factor-α(TNF-α),interferon-γ(IFN-γ)and interferon inducible protein-10(IP-10)among 3groups and the time for rash relief,remission rate of hematuria and proteinuria,recurrence rate within 1 month in HSP children were observed and compared.Results The ratios of Treg cell subsets and Th17 cell subsets after treatment had no statistical difference between the pidotimod treatment group and the control group(P0.05),while which had the statistical difference between the conventional treatment group and the control group(P0.05);the plasma IL-17,IFN-γ,IP-10 and TNF-αexpression levels had no statistical differences between the pidotimod treatment group and the control group(P0.05),but the IL-17 and IFN-γexpression levels in the conventional treatment group were still significantly higher than those in the control group.the remission rate of simple hematuria in the pidotimod treatment group was significantly higher than that in the conventional treatment group,while the recurrence rate within 1month after treatment was significantly lower than that in the conventional treatment group.Conclusion The application of pidotimod therapy in the treatment of children with HSP can significantly correct the imbalance of Treg cell subsets and Th17 cell subset,decrease the expression levels of the cytokines such as IL-17 and IFN-γ,suppress the autoimmune reaction so as to achieve the effects of significantly alleviating the impairment of renal function and reducing the short term recurrence rate,which is benefit for the improvement of prognosis in the children patients with HSP.
【CateGory Index】: R725.9
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【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 JIN Ling;LING Jie;Department of Paediatrics,Traditional Chinese Medical Hospital of Pujiang;Clinical Laboratory,The First People' s Hospital of Taizhou;;Curative effect and security of pidotimod oral liquid on the prevention and treatment of childhood with asthma[J];Practical Pharmacy and Clinical Remedies;2014-02
2 ZHANG Wen-wen;CHEN Hui-ru;Department of Pharmaceutical Technology and Biological Engineering,Changzhou Institute of Engineering Technology;;Progress in Synthesis of New Immunomodulating Agent Pidotimod[J];Chemical Reagents;2014-11
3 JIANG Feng(Department of Pediatrics,Jimo Maternal and Child Health Hospital,Jimo 266200,China);Clinical Research of Pidotimod Oral Soluion in Treatment of Children with Reiterative Respiratory Tract Infections[J];Guide of China Medicine;2013-07
4 LIU Lu,ZHAO Jin-feng(Delingha Hospital of TCM,Qinghai Delingha 087100,China);Clinical Efficacy Observation of Pidotimod Combined with Ligustrazine in the Treatment of Children with Bronchial Asthma[J];China Pharmacy;2013-23
5 WANG Chang,MO Zhengbo Department of Dermatology and Venerology,The Encephalic Hospital of Hunan Province,Hunan 410007,China;Recurrence of Condyloma Acuminatum and immunomodulatory effects of Pidotimod[J];The Chinese Journal of Human Sexuality;2013-04
6 ZHANG Gaoming,YANG Ling,ZHANG Lijun(The Affiliated Hospital of Aviation Medicine Research Center of Air Force,Beijing,100089);Effect observation of combining isotretinoin and pidotimod with cryotherapy on stubborn and refractory verruca plantaris in 23 cases[J];Journal of Clinical Medicine in Practice;2013-05
7 LIU Jingxia Department of Asthma,the Children's Hospital of Baoding City,Hebei Province,Baoding 071051,China;Study on the influence of Pidotimod on attack times,pulmonary function and immune function of children with asthma[J];China Medical Herald;2013-12
8 Li Ling;Gou Hongbo;Wen Yana;Dai Chuncai;Department of Paediatrics,People's Hospital of Changshou District;;Observation on curative effects of pidotimod combined with budesonide on children with bronchial asthma[J];Medical Journal of National Defending Forces in Southwest China;2013-12
9 XIE Li;LIU Rong;LI Yan;YU Jing;Department of Pediatrics,Central Hospital of Mianyang;;Efficacy and Safety of Pidotimod Combined With Budesonide Aerosol in the Treatment of Bronchial Asthma in Children[J];Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition);2013-06
10 ;Evaluation of the efficacy of pidotimod combined with compound methoxyphenamine in the treatment of post-infectious cough[J];Chinese Journal of Lung Diseases(Electronic Edition);2014-02
【Secondary Citations】
Chinese Journal Full-text Database 5 Hits
1 Lin Da-dong(Department of Dermatology,PLA No.180 Hospital,Quanzhou Fujian 362000,China);Comparative study of intermitant and suppressive pidotimod therapy for recurrent genital herpes[J];Clinical Journal of Medical Officers;2010-06
2 LI Yi-ping, CAI Hui, Gu Yuan-hui, LI Yuan (Department of General Surgery, The People's Hospital of Gansu Province, Lanzhou, 730000, China);Effects of pidotimod on immune function of patients with chronic hepatitis C[J];Journal of Lanzhou University(Medical Sciences);2006-01
3 LU Ping,ZHANG Wei-chun,LIN Jing-hui;Curative Effect of Pidotimod on Respiratory Infection of 105 Children[J];Journal of Applied Clinical Pediatrics;2008-10
4 Wang Xuezhou(Department of Obstetrics & Gynecology,Third People's Hospital of Cangnang City,Zhejiang Cangnang 325800,China);Prophylactic Effect of Condyloma Acuminatum Relapse by Pidotimod on Post-CO_2 laser Treatment[J];China Pharmacist;2010-02
5 ZHANG Qi1,LI Lan2,LI Bai-en1,XU Li-min1.(1.Department of Pediatrics,Ningbo Women and Children Hospital of Zhejiang Province,Ningbo 315010;2.Department of Pediatrics,Zhejiang Traditional Chinese Medical Hospital,Hangzhou 310006);42 cases clinical observation on the recurrence of Henoch-Schonlein purpura by pidotimod[J];Chinese Journal of Birth Health & Heredity;2008-05
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