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《International Journal of Laboratory Medicine》 2015-01
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Effects of pidotimod on Treg/Th17 cell immunity in children with Henoch-Schonlein purpura

Liu Caixia;Luo Huili;Yao Yuan;Li Xinchao;Department of Pediatrics,Affiliated Taihe Hospital,Hubei Medical College;  
Objective To observe and analyze the effects of pidotimod on the immunity of Treg/Th17 cells in the children with Henoch-Schonlein purpura(HSP).Methods 60 cases of HSP were selected and randomly divided into the pidotimod treatment group and the conventional treatment group,30 cases in each group.30 healthy children were selected as the control group.The conventional treatment group was given the routine therapy,while the pidotimod treatment group was added with oral pidotimod dispersible tablets on the basis of the routine therapy.The ratios of Treg cell subsets and Th17 cell subsets,the plasma expression levels of interleukin-17(IL-17),tumor necrosis factor-α(TNF-α),interferon-γ(IFN-γ)and interferon inducible protein-10(IP-10)among 3groups and the time for rash relief,remission rate of hematuria and proteinuria,recurrence rate within 1 month in HSP children were observed and compared.Results The ratios of Treg cell subsets and Th17 cell subsets after treatment had no statistical difference between the pidotimod treatment group and the control group(P0.05),while which had the statistical difference between the conventional treatment group and the control group(P0.05);the plasma IL-17,IFN-γ,IP-10 and TNF-αexpression levels had no statistical differences between the pidotimod treatment group and the control group(P0.05),but the IL-17 and IFN-γexpression levels in the conventional treatment group were still significantly higher than those in the control group.the remission rate of simple hematuria in the pidotimod treatment group was significantly higher than that in the conventional treatment group,while the recurrence rate within 1month after treatment was significantly lower than that in the conventional treatment group.Conclusion The application of pidotimod therapy in the treatment of children with HSP can significantly correct the imbalance of Treg cell subsets and Th17 cell subset,decrease the expression levels of the cytokines such as IL-17 and IFN-γ,suppress the autoimmune reaction so as to achieve the effects of significantly alleviating the impairment of renal function and reducing the short term recurrence rate,which is benefit for the improvement of prognosis in the children patients with HSP.
【CateGory Index】: R725.9
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