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《International Journal of Laboratory Medicine》 2015-01
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Study on correlation between plasma NT-pro BNP level and heart function in children with heart failure

Gui Ruifeng;Li Chaowei;Guo Huaguo;Li Yan;Department of Clinical Laboatory,Huanggang Municipal Central Hospital;  
Objective To investigate the relationship between the plasma NT-pro BNP level and the hear function in children patients with heart failure.Methods 30 children patients with heart failure and 30 healthy children were selected as the patients group and the control group respectively.The plasma NT-pro BNP level was detected in the patients group before and after treatment and the control group.The changes of heart functional indexes and the clinical symptoms in the patients group were detected,the detection results and the plasma NT-pro BNP levels were performed the correlation retrospective analysis.Results The plasma NT-pro BNP level before treatment in the patients group was significantly higher than that in the control group,there was the statistically significant difference between them(P0.05).After treatment,the clinical symptoms in the patients group were obviously improved,the plasma NT-pro BNP level was significantly decreased and LVEF by ultrasound was also increased,the differences were statistically significant(P0.05).The plasma NT-pro BNP level after treatment in the patients group was obviously higher than that in the control group with statistical difference between them(P0.05).The plasma NT-pro BNP level before and after treatment in the patients group demonstrated a negative correlation with LVEF(r=-1.32,r=-1.78).Conclusion Detecting the plasma NT-pro BNP level in children patients with heart failure has the important clinical guidance significance for the diagnosis,disease condition evaluation,prognostic evaluation and cardiac function grading in the children patients with heart failure.
【CateGory Index】: R725.4
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