Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《International Journal of Laboratory Medicine》 2015-02
Add to Favorite Get Latest Update

Expression of apolipoprotein A-I in prostate cancer and benign prostatic hyperplasia

Gong Bei;Lei Ting;Zhang Man;Clinical Laboratory Center,Beijing Shijitan Hospitals Affiliated to Capital Medical University;  
Objective To investigate the different expression of apolipoprotein A-I(ApoA-1)in prostate cancer and benign prostatic hyperplasia,and to explore the new indicators of prostate diseases.Methods The immunochemistry was used to detect the expression of ApoA-1in prostate cancer tissues(13cases)and benign prostatic hyperplasia tissues(37cases).The correlations between the level of ApoA-1and the serum prostate antigen series total prostate specific antigen(tPSA),free prostate specific antigen(fPSA),the ratio of fPSA and total PSA(fPSA/tPSA),cholesterol(CHOL),triglyceride(TRIG),low-density lipoprotein-cholesterol(LDL-C)and high-density lipoprotein-cholesterol(HDL-C)levels were analyzed.Results In 13 cases of prostate cancer,ApoA-1showed strongly positive expression,while ApoA-1was weak positive stained or even negative in 37 cases of benign prostatic hyperplasia,a significant difference was observed between them(t=-6.182,P0.05).Within the same range of PSA levels,ApoA-1was obviously higher in the cancer group than that of the benign prostatic hyperplasia patients(P0.05).The LDL-C level of prostate cancer group(3.02±0.79)mmol/L was higher than that of benign prostatic hyperpalsia group(2.14±0.78)mmol/L,the difference was statistically significant(P0.05).The HDL-C level of prostate cancer group(1.27±0.33)mmol/L was lower than that of benign prostatic hyperpalsia(1.70±1.02)mmol/L,The difference was statistically significant(P0.05).There was a significant correlation between the level of ApoA-1and the level of cholesterol(r=0.332,P0.05).Conclusion The expression of ApoA-1is obvious different between the patients with prostate cancer and the patients with benign prostatic hyperplasia.
【Fund】: 北京市自然科学基金项目(7122086)
【CateGory Index】: R737.25;R697.3
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved