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《International Journal of Laboratory Medicine》 2015-02
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The function of Follistatin-like protein 1 in patients with rheumatoid arthritis

Zhang Hong;Zhang Ping;Zhou Hongxing;Wang Yuji;Li Xiaohong;Department of Clinical Laboratory,Changzhou TCM Hospital Affiliated to Nanjing TCM University;Department of Clinical Laboratory,Changzhou Second People′s Hospital Affiliated to Nanjing Medical University;Department of Orthopedics,Changzhou Second People′s Hospital Affiliated to Nanjing Medical University;  
Objective To explore the correlation between the level of follistatin-like protein 1(FSTL1)and the disease activity in patients with rheumatoid arthritis(RA).Methods Twenty patients with RA in observation group,twenty patients without RA in contrast group.Serum FSTL1 levels were detected before and after treatment by enzyme linked immunosorbent assay(ELISA),erythrocyte sedimentation rate(ESR)were detected by Westergren,the levels of C-reactive protein(CRP)and rheumatoid factor(RF)were detected by Immune Transmission Turbidimetric,cyclic citrullinated peptide CCP antibody was detected by CCP antibody ELISA kit,Disease Activity Score in 28Joints(DAS28)were used to evaluate the disease activity.The level of FSTL1 in fibroblast-like synoviocytes was detected by Western Blotting.Results Serum FSTL1 level in the observation group was correlated with ESR,CRP,RF,CCP antibody and DAS28score(P0.05).FSTL1 level in the observation group was significant higher than that of the control group(P0.05),and the FSTL1 level was significantly diminished in the observation group after receiving clinical treatment(P0.05).Conclusion Serum FSTL1 level might serve as a serological inflammatory marker of disease activity in RA patients.
【CateGory Index】: R593.22
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