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《International Journal of Laboratory Medicine》 2015-02
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Correlation between ApoB/ApoA-1 and insulin resistance in patients with type 2-diabetes

Ye Jianpin;Chen Xiaoyan;Department of Clinic Laboratory,Xiamen Airlines Company;Department of Clinic Laboratory,the First Hospital Nanping Affiliated to Fujian Medical University;  
Objective To investigate the relationship between the ratio of apolipoprotein B and apolipoprotein A1(ApoB/ApoA-1)and insulin resistance(IR)in patients with type 2-diabetes.Methods The serum samples of 180 type 2-diabetes patients in Nanping were collected and detected triglyceride(TG),cholesterol(TC),high-density lipoprotein-cholesterol(HDL-C),low-density lipoprotein(LDL-C),apolipoprotein A1(ApoA-1),lipoprotein B(ApoB),fasting plasma glucose(GLU),fasting serum insulin(FINS),fasting serum c-peptide(Cp)and glycosylated hemoglobin(HbA1c),then calculated ApoB/ApoA-1ratio and insulin resistance index(Homa-IR).According to the quarterback numerical of 180 type 2-diabetes patients ApoB/ApoA-1,all the patients were divided into group A,B,C,D.The relationship between the ApoB/ApoA-1and Homa-IR was analyzed.Results Compared with the good control of glucose group,the levels of TC,LDL-C,ApoB,GLU,Homa-IR and ApoB/ApoA-1in the poor control of glucose group were significantly increased(P0.05).The IR risk in groups with higher ApoB/ApoA-1were far higher than that of groups with lower ApoB/ApoA-1(P0.01).Conclusion There was a significant relationship between the ApoB/ApoA-1and IR in patients with type 2-diabetes,and as the ApoB/ApoA-1increased,the incidence of IR increased too.
【CateGory Index】: R587.1;R446.1
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