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《International Journal of Laboratory Medicine》 2015-02
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Analysis on the pathogenic distribution and drug-resistance in malignant tumor patients with hospital-acquired fungus infection

Liao Xuefeng;Li Mi;Department of Clinical Laboratory,Xianggang Hospital of Xiangtan City in Hunan;  
Objective To explore the distribution character,the factors of infection and drug-resistance in malignant tumor patient with hospital-acquired Fungus infections,provide the basis for clinical treatment of fungal infections.Methods A total of 324 specimens were collected from malignant tumor patients,then cultured and did drug sensitive test from January 2012 to December2013.Results There was 96 strains fungus were detected from 324 specimens,the infection rate was 29.6%.The most infection portion was respiratory accounting for 74.0%.The most bacteria type was Candida albicans accounting for 67.7%,followed by Candida tropicalis accounting for 14.6%.Antimicrobial drug abuse,a large number using of hormones and invasive procedures were risk factors for Fungus infections.The highest resistance drug of five major yeast-like Fungus was itraconazol,but these were all sensitive to 5-fluorocytosine and amphotericin B.Conclusion Common Candida has a certain resistance to commonly used antifungal agents,the monitoring and control of Candida should be strengthen,and use antifungal agents rationally according to the results of drug sensitive test.
【CateGory Index】: R446.5
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