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《International Journal of Laboratory Medicine》 2015-02
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Distribution characteristic and antibiotic resistance of Acinetobacter baumannii from 2010 to 2013

Chen Weimei;Huang Haonan;Department of Clinical Laboratory,Longyan First Hospital Affiliated to Fujian Medical University;  
Objective To explore the distribution characteristic and antibiotic resistance of Acinetobacter baumannii(A.baumannii)from 2010 to 2013.Methods The drug resistance and distribution were analyzed retrospectively by Whonet 5.6software from 2010 to 2013.Results There were 1 038 strains of A.baumannii detected out,primarily isolated from sputamentum samples,making up 81.5%,and most strains were from intensive-care unit(ICU).The resistance rate to polymyxin was the lowest as0.6%.The resistance rates to cefoperazone-sulbactam,imipenem and meropenem were 26.4%,35.5% and 35.9% respectively.Imipenem-susceptible strains showed lower resistance rate to polymyxin B(0.5%),followed by meropenem(2.1%),cefoperazonesulbactam(3.2%)and ampicillin-sulbactam(9.9%),the sensitive rate to cefotaxime and ceftriaxone were less than 30%,the resistance to other antimicrobial agents were greater than 70%.Imipenem-resistance strains showed lower resistance to polymyxin B(0.8%)and cefoperazone-sulbactam(65.5%),the resistance to other antimicrobial agents were greater than 86%,mainly distributed in ICU and neurosurgery.Conclusion Carbapenems and cefoperazone-sulbactam were the preferred drug to A.baumannii.The strains that resistance to carbapenem antibiotics should take combination treatment.It needs to enhance precautionary measures and monitor drug resistance.
【CateGory Index】: R446.5
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Chinese Journal Full-text Database 1 Hits
1 LIN Li1,2, ZHOU Qi-xin1 , LING Bao-dong2(1. Division of Pharmacology, Chongqing Medical University, Chongqing 400016, China;2.Department of Pharmacology, Pharmaceutical Research Institute ,North Sichuan Medical College, Nanchong 637007, China);Progress on Carbapenem Resistance Mechanisms of Acinetobacter baumannii[J];World Notes on Antibiotics;2007-03
Chinese Journal Full-text Database 3 Hits
1 Ling Bao-dong (Institute of Materia Medica and Department of Pharmacology,North Sichuan Medical College,Nanchong 637007);Multidrug resistance in Acinetobacter baumanni:Mechanisms and anti-infective therapy[J];Chinese Journal of Antibiotics;2010-04
2 Liu Zhen-ru and Ling Bao-Dong (Institute of Materia Medica and Department of Pharmacology,North Sichuan Medical College,Nanchong 637007);Advances in studying 16S rRNA methylation enzymes in multiple drug-resistant Acinetobacter baumannii[J];Chinese Journal of Antibiotics;2011-10
3 Gong Yan-fei;Zeng Qiang;Liu Xiang-lin;Zhang Zu-ping;Chen Zhong-xiang;Peng Hua;The First People's Hospital of Yueyang;Department of Pathogen Biology, School of Basic Medicine, Central South University;;In vitro effect of cefoperazone/sulbactam combined the tigecyclin on imipenem-resistant Acinetobacter baumannii clinical isolates[J];Chinese Journal of Antibiotics;2013-12
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