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《International Journal of Laboratory Medicine》 2015-02
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The value of combined detection of perinuclear anti neutrophil cytoplasmic antibody and fecal calprotectin in clinical diagnosis of ulcerative colitis

Ma Rong;Li Yuzhong;Li Xiaolan;Department of Clinical Laboratory,the Second Affiliated Hospital of Dalian Medical University;  
Objective To investigate the clinical value of the combined detection of perinuclear anti neutrophil cytoplasmic antibody(pANCA)in the blood and fecal calprotectin(FCP)in diagnosis of ulcerative colitis(UC)and evaluation of its activity.Methods A total of 119 patientts with UC were selected into the study group,including 68 patients in active stage,51 patients in remission stage.Other 45 patients with other digestive tract disease were selected into the disease control group.Other 42 healthy people were selected in the normal control group.The level of pANCA in blood was detected by indirect immunofluorescence assay(IIF),the FCP was detected by enzyme linked immunosorbent assay(ELISA)in stool.Results The positive rates of pANCA in UC exacerbation and remission period were significant higher than those of the disease control group and the normal control group,the differences were statistically significant(P0.05).The sensitivity and specificity of pANCA detection were 68.90%,98.85% respectively.FCP level of UC in activity period was significantly higher than that in remission,the difference was statistically significant(P0.05),FCP in UC remission was higher than that in the disease control group,the difference was statistically significant(P0.05),FCP level in disease control group had no significant difference with the normal control group(P0.05).The sensitivity and specificity rate of FCP detection in diagnosis for UC were 74.79%,89.65%respectively.The sensitivity and specificity rate of the combined detection were 85.71%,89.65% respectively.Conclusion There is a good correlation between the level of FCP and the activity of UC,and it could distinguish UC activity and remission period.The level of pANCA could be used as a secondary indicators for diagnosis of UC.The combined detection of pANCA and FCP could provide a reliable theoretical basis for activity assessment,treatment effect observation and prediction of recurrence in patients with UC disease.
【CateGory Index】: R574.62;R446.6
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