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The mechanism of Chaihu Shugan powder regulating the signal transduction pathway in rats with "angry injury live"

YANG Junping;WANG Ying;XIAO Liang;Department of Clinical Laboratory,The Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine;  
Objective To observe the effect of Chaihu Shugan powder on neuroendocrine immunity and mediator response mediated by hypothalamus-pituitary-adrenal axis,locus coeruleus-sympathetic-adrenal medulla in rats with "angry liver injury".Methods 120 Wistar rats were randomly divided into normal control group,model group,traditional Chinese medicine(TCM)high-dose group,TCM medium-dose group,and TCM lowdose group.After 30 seconds of electrification,the bilateral diaphragm was destroyed the "angry injury liver" stress model was established.In the stress animal model,the TCM low,medium and high-dose group were given 0.3,0.6,1.2 g/(kg·d),respectively.Results Compared with the model group,the expression of Gammaaminobutyric acid type A receptor(GABAA)α2 mRNA in the hippocampus and the progesterone content in the cerebral cortex increased(P0.05),and the contents of Norepinephrine(NE),5-hydroxytryptamine(5-HT)and dihydroxyphenylacetic acid(DOPAC)in the hippocampus of rats decreased(P0.05).The contents of NE,5-HT,dopamine and DOPAC in brainstem tissues decreased(P0.05).Conclusion Through multiple targets,Chaihu Shugan powder can regulate many physiological reactions related to "anger liver" rats.
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