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Effects of curcumin on intracellular and extracellular heat shock protein 70 in rat model of thrombosis

REN Biqiong;TIAN Xuefei;LUO Shudi;XU Fei;LIU Junlong;CHEN Wei;Department of Clinical Laboratory,The Second People′s Hospital of Hunan;School of Clinical Medicine,Hunan University of Traditional Chinese Medicine;  
Objective Effects of curcumin on thrombosis model in rats and its relationship with damage-associated model molecule(DAMP)heat shock protein 70(HSP70)were studied with turmeric extract as reference.Methods After 14 days′intragastric administration of curcumin and turmeric extract,thrombosis models were established in rats by physical method.Blood samples and vascular tissues of rats were obtained,and sham operation group and distilled water group as control group.Plasma HSP70 levels were detected by ELISA and the expression of HSP70 in vascular tissues of rats was measured by immunohistochemical staining.Results The plasma HSP70 level in thrombotic model group was significantly higher than that in shamoperated group(P=0.003).The plasma HSP70 level in curcumin low and high dose group was significantly lower than that in sham-operated group(P=0.005,0.002).Compared with sham-operated rats,the expression of HSP70 in vascular tissues of thrombotic model rats was increased.Curcumin could increase the expression of HSP70 in vascular tissues of thrombotic model rats,but curcuma extract had no such effect.Conclusion The anti-inflammatory effect of curcumin is related to the increase of intracellular HSP70 expression and the decrease of extracellular HSP70.The anti-inflammatory effect of turmeric extract may be through other mechanisms.
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