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Application of laboratory medicine in the randomized controlled clinical research of Shandan tea in the treatment of non-alcoholic fatty liver disease

WANG Yiyi;LU Qian;ZHANG Jue;ZHANG Bin;LIN Hai;LU Chuancui;Department of Clinical Laboratory,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine;Department of Clinical Laboratory,Shanghai Pudong New Area Health Care Hospital for Maternal and Child;  
Objective To find the clinical efficacy of diet,exercise intervention on Non-alcoholic simple fatty liver disease,and also to observe the clinical efficacy of diet,exercise intervention combining with traditional Chinese medicine(Shandan tea)on non-alcoholic simple fatty liver disease.Methods The study collected 200 cases of NAFLD patients,which were divided into control group and treatment group randomly.Each group lost 5 patients in the process and 190 patients finished the experiment.Both of the groups were given diet management and exercise intervention.The treatment group also had Chinese medicine tea(Danshen 15 g,hawthorn 15 g,Semen Cassiae 15 g,liquorice 6 g and the control group did not have.Both of the groups were observed for 24 weeks to compare the change of fibroscan CAP fat quantitative,BMI,liver function,renal function,blood lipid level and redox index,which was used to assess the clinical efficacy and safety of Chinese medicine(Shandan tea)intervention on non-alcoholic simple fatty liver disease.Results Compared with before treatment,the CAP index of the treatment group decreased significantly(P0.001),and the difference in the control group was statistically significant(P0.05),and the difference between the treatment group and the control group was statistically significant(P0.001).Compared with before treatment,the BMI index of the treatment group decreased,and the difference was statistically significant(P0.01),and the difference in the control group was statistically significant(P0.05).There were significant differences between the two groups(P0.05).Compared with before treatment,the liver function indexes of the treatment group,alanine aminotransferase(ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP),gamma glutamyltransferase(GGT),leucine aminotransferase(LAP),prealbumin(PA)and cholinesterase(CHE)decreased significantly,and the differences were statistically significant(P0.05).The AST,LAP,PA and CHE in the control group were significantly decreased in the control group,(P0.05),but there were no significant differences in ALT,GGT and ALP(P0.05).Compared with the control group,ALT,GGT and LAP in the treatment group were significantly lower(P0.05),while AST,ALP,PA and CHE had no significant difference(P 0.05).Compared with before treatment,there was no significant difference in Urea nitrogen(BUN),uric acid(URIC),creatinine(CREA)between the two groups(P0.05),but there was no significant difference in BUN,URIC and CREA between the treatment group and the control group(P0.05).Compared with before treatment,there was no significant difference in blood lipid indexes such as triglyceride(TG),cholesterol(CHOL),low density lipoprotein cholesterol(LDL-C)and high density lipoprotein cholesterol(HDL-C)between the treatment group and the control group(P0.05),while free fatty acid(FFA)decreased significantly(P0.05).There was no significant difference in the levels of HOL,HDL-C,LDL-C and FFA between the treatment group and the control group(P0.05);there was no significant difference in the levels of TG,CHOL,HDL-C,LDL-C and FFA between the treatment group and the control group(P0.05).Compared with before treatment,the redox index of superoxide dismutase(SOD)in treatment group and control group decreased significantly,with significant difference(P0.05),and homocysteine(HCY)increased significantly(P0.05);there was no significant difference in the changes of SOD and HCY between treatment group and control group(P0.05).Conclusion Compared with before treatment,diet management,exercise intervention can improve some levels of NAFLD patients′liver function index,diet management,exercise intervention and Chinese medicine(Shandan tea)can significantly reduce the levels of CAP,BMI,part of liver function levels and part of blood lipid levels.Compared with the control group,the treatment group′s CAP,BMI,ALT,GGT,LAP level are lower,which makes a great efficacy.
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