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Efficacy of methotrexate combined with Juanbi Bushen decoction in the treatment of rheumatoid arthritis and its effect on ESR,CRP,RF and anti-CCP antibody

SHU Biying;CAI Feng;Department of Clinical Laboratory,Shanghai Municipal Hospital of Traditional Chinese Medicine Affiliated to Shanghai University of Traditional Chinese Medicine;  
Objective To investigate the clinical effect of methotrexate combined with Juanbi Bushen decoction on rheumatoid arthritis and its effect on laboratory indexes.Methods Totally 76 patients with rheumatoid arthritis treated in the hospital from October 2016 to June 2018 were randomly divided into control group and observation group with 38 cases each.The patients in the control group were treated with methotrexate and the patients in the observation group were treated with Juanbi Bushen decoction and methotrexate.Results The total effective rate of the observation group was 92.11%,which was significantly higher than that of the control group(73.68%)(P0.05).The clinical symptoms and signs(morning stiffness time,joint swelling number,joint tenderness number,joint pain degree)in the observation group were significantly better than those in the control group(P0.05).The levels of ESR,CRP,RF,anti-CCP antibody in the observation group were higher than those in the control group(P0.05).Conclusion The treatment of rheumatoid arthritis with methotrexate combined with Juanbi Bushen decoction can significantly improve the joint tenderness,swelling,morning stiffness,joint pain and the levels of ESR,CRP,RF,and anti-CCP antibody.The anti-inflammatory and immunosuppressive effects are more significant than those of methotrexate alone.
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