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Effect of Bushen Huoxue Decoction on serum OPG,RANKL concentrations in patients with osteoporotic thoracolumbar vertebral compression fracture

LIU Yihui;CHEN Dongmei;WANG Lizhong;GONG Long;Department of Orthopaedics,Shunyi Hospital,Beijing Chinese Medicine Hospital;Electric Power Teaching Hospital of Capital Medical University;  
Objective To investigate the effect of Bushen Huoxue Decoction on serum osteoprotegerin(OPG)and nuclear factor kappa B receptor ligand(RANKL)concentrations in patients with osteoporotic thoracolumbar vertebral compression fractures(OTCF).Methods Ninety patients with OTCF from March 2016 to March 2017 were randomly divided into control group and treatment group.Both groups were treated with vertebral bodyplasty.In addition to that,the treatment group was given Bushen Huoxue Decoction,1 dose/d for 3 months.According to the Chinese osteoporosis quality of life short-form questionnaire(COQOL),the quality of life scores before and after treatment were evaluated.The serum concentrations of OPG and RANKL were compared before and after treatment.Results After treatment,the pain symptoms,physical function,social adaptability,and mental function scores of the two groups were lower than those before treatment.However,the scores of COQOL indexes in the treatment group decreased more significantly,and the difference was statistically significant(P0.05).Compared with the control group,the serum OPG concentration of the treatment group was(354.64±37.46)ng/L,and the serum OPG concentration of the control group was(333.28±35.58)ng/L.The treatment group was significantly higher than the control group,the difference was Statistical significance(P0.05).The serum RANKL content of the treatment group was(8.35±0.82)ng/L,and the serum RANKL concentration of the control group was(10.54±1.31)ng/L.The treatment group was significantly lower than the control group,the difference was statistically significant(P0.05).Conclusion Bushen Huoxue Decoction combined with percutaneous vertebroplasty is effective in the treatment of OTCF.Bushen Huoxue Decoction can regulate the content of OPG and RANKL in patients,which can help improve the efficacy of OTCF.
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