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Association of lipoprotein(a)and coronary heart disease with LPA KIV-2 copy number variation in Han population of Northern China

ZHENG Ye;TENG Shichao;JIANG Xiaofeng;Department of Clinical Laboratory,the Fourth Affiliated Hospital of Harbin Medical University;Department of Emergency Medicine,the Fourth Affiliated Hospital of Harbin Medical University;  
Objective To investigate the relationship between lipoprotein(a)[Lp(a)]and the copy number variation of LPA gene kringle IV type 2(KIV-2)and coronary heart disease in Han population of Northern China.Methods To tally 275 patients who underwent emergency departments of internal medicine and cardiology from October 2016 to March 2018 were enrolled in the Fourth Affiliated Hospital of Harbin Medical University.84 patients with coronary heart disease diagnosed by clinical symptoms and imaging methods were defined as CHD group,and 191 patients with coronary stenosis50% were defined as control group.LPA KIV-2 was extracted from whole blood DNA.Quantitative real-time PCR(qPCR)was used to detect LPA KIV-2 copy number and serum Lp(a)levels were measured in all patients.Results Lp(a)was negatively correlated with KIV-2 copy number(r=-0.33,P0.01),and under the age stratification,each age group increased with the LPA KIV-2 copy number,the Lp(a)level decreased(P0.05).In the experiment,through stepwise Logistic regression analysis,it was concluded that age,gender,LPA KIV-2 copy number,Lp(a),TG and HDL-C had an effect on coronary heart disease.Conclusion The LPA KIV-2 copy number is inversely related to Lp(a)level in the Han population of Northern China.Serum Lp(a)level and LPA KIV-2 copy number are risk factors for coronary heart disease.
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