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The relationship between the new parameters of red blood cells and reticulocytes and TCM syndrome types of anemia diseases

TANG Yufeng;WANG Fengmei;LI Jun;GUO Huijuan;TANG Xudong;LI Qi;SHANG Xiaohong;LI Ronghai;Department of Laboratory Medicine,Xiyuan Hospital Affiliated to China Academy of Chinese Medical Science;Department of Hematology,Xiyuan Hospital Affiliated to China Academy of Chinese Medical Science;  
Objective To investigate the relationship between the new parameters of red blood cells and reticulocytes and TCM syndrome-type of anemia diseases.Methods Venous blood of 448 cases for healthy control and 428 patients with anemia diseases were collected.Reticulocyte hemoglobin content(Ret-He),red blood cell hemoglobin(RBC-He),difference of Ret-He and RBC-He(D-He),percentage of hypochromia RBC(Hypo-He%),percentage of hyperchromia RBC(Hyper-He%),fragments of red blood cell(FRC%),percentage of microcyte(MicroR%),percentage of macrocyte(MacroR%)were detected using Sysmex XT-4000 iautomatic blood analyzer.The reference intervals were established for healthy controls.Differences between healthy control and patients with anemia diseases for those TCM syndrome divided into four groups including pixuxuekui,shenxuesuikui,pishenkuixu and pixutanshi.Results The differences of Ret-He and D-He between control group and case group each type had no statistical significance(P0.05).The level of RBC-He in control group was less than that of shenxusuikui group(P=0.005).The levels of FRC%,Hypo-He%,HyperHe%,MicroR% were less than those of each case group(P0.005),and the level of MacroR% was less than pishenkuixu group(P=0.000).Conclusion The new parameters of red blood cells and reticulocytes will benefit diagnosis and differential diagnosis to anemia disease and provide more reference information and objective basis.The parameters is conducive to syndrome-type differentiation of TCM for anemia diseases.
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