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In vitro antibacterial effect of coptidis decoction on 100 isolates of multi-drug resistant bacteria

ZHOU Fangfang;YANG Wenyi;WANG Lei;Department of Clinical Laboratory,Shanghai Eighth People′s Hospital;Department of Clinical Laboratory,Zhoushan Branch of Shanghai Ruijin Hospital;  
Objective To observe the antibacterial effect of coptidis decoction on 100 isolates of multi-drug resistant bacteria in vitro,and to find new ways and methods for the treatment of multi-drug resistant bacteria infection.Methods A total of 100 multi-drug resistant strains were selected from 868 common clinical isolates.The minimum inhibitory concentrations(MIC)of coptidis decoction for multi-drug resistant isolates was detected by micro-broth dilution method.Results The top 10 bacteria in the 868 clinical common bacteria were Escherichia coli,Staphylococcus aureus,Klebsiella pneumoniae,Pseudomonas aeruginosa,Acinetobacter baumanii,Enterococcus faecalis,Enterococcus faecium,Proteus mirabilis,Proteus cloacae and Staphylococcus haemolysin.The rates of multi-drug resistant bacteria were 61.19%,68.31%,69.77%,78.13%,98.72%,86.67%,100.00%,60.00%,62.86%and 77.78%,respectively.The antibacterial activity of coptidis decoction had better antibacterial activity against gram-positive cocci,the effects from better to worse were as follows,Staphylococcus haemolyticus,Staphylococcus aureus,Enterococcus faecium,Enterococcus faecalis,the MICs of which were≤2.34 mg/mL,4.69-18.75 mg/mL,18.75-75.00 mg/mL and 75.00 mg/mL,respectively.Coptidis decoction for detoxification showed no obvious antibacterial effects against gram-negative bacilli,such as Escherichia coli,Klebsiella pneumoniae,Proteus mirabilis,Pseudomonas aeruginosa,Enterobacter cloacae and Acinetobacter baumannii,the MICs of which were all≥75.00 mg/mL.Conclusion Coptidis decoction for detoxification showed antibacterial effect on gram-positive cocci,while had no obvious antibacterial effect on gram-negative bacilli.
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