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In vitro interference of Tanreqing injection on routine clinical biochemical assays

YIN Yuan;ZHAO Yanrong;WANG Zhengyin;LI Liangliang;GU Zhengjing;WANG Weiling;Department of Clinical Laboratory,Shanghai Traditional Chinese MedicineIntegrated Hospital;  
Objective To investigate the interference of Tanreqing injection on 8 clinical biochemical assays.Methods The concentrations of 8 analytes were determined and prepared through mixed serum.10 times of the therapeutic concentration of Tanreqing injection was prepared and used as the interference sample,and the control sample was injection water.The interference of the interference sample and the control sample were accessed through testing 8 clinical biochemical items respectively.Furthermore,dose effect test was conducted to determine the concentration and intensity of the interference drugs.Through the paired difference test,aevaluation on the Tanreqing injection interfering with the sarcosine oxidase and alkaline picric acid methods which were used to analyze serum creatinine was held.Results The paired difference tests showed negative interference when the concentration of Tanreqing injection in serum was 40 mL/L and the concentrations of TG,UA and Cr(enzymatic assay)in samples were 5.87 mmol/L,502μmol/L and 142μmol/L,respectively.The deviations from drug-free serum were-27.21%,-59.80%and-46.21%.The dose effect tests were carried out on 3 negative interfering assays,which showed the lowest concentrations of Tanreqing injection that could cause interference on TG,Cr and UA detection were 17.06,1.47 and 3.06 mL/L respectively.The paired difference test showed Tanreqing injection had no interference to the determination of creatinine on basic picric acid method.Conclusion The interference of Tanreqing injection exists on some clinical biochemical assays.
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