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In vitro antibacterial study of tanreqing injection combined with Imipenem and cefoperazone/sulbactam for extensively drug resistant Klebsiella pneumoniae

MA Dongmei;TAO Qingchun;QI Hongwei;Department of Clinical Laboratory,Beijing University of Chinese Medicine of third Affiliated Hospital;  
Objective To discuss antibacterial effect of Tanreqing injection combined with Imipenem and Cefoperazone/sulbactam on extensively drug resistant Klebsiella pneumoniae in vitro.Methods This experiment use the broth dilution method to determine the minimal inhibitory concentration(MIC)of the different concentrations of Tanreqing injection and Imipenem,Tanreqing injection and cefoperazone/sulbactam in 30 strains of the clinical extensively drug resistant Klebsiella pneumoniae,the fractional inhibitory concentration(FIC)index was calculated to determine the combined effect of the antibiotics.Results FIC index results of Tanreqing combined with Imipenem showed:FIC0.5 is 43.3%,0.5FIC≤1 is 30%,1FIC≤2 is 20%,FIC2 is 6.7%,FIC index results of Tanreqing combined with Cefoperazone/sulbactam showed:FIC0.5 is0%,0.5FIC≤1 is 13.3%,1FIC≤2 is 33.3%,FIC2 is 53.3%.Conclusion The combined effect of tanreqing injection and cefoperazone/sulbactam is most irrelevant and antagonistic effect,the combined effect is worse.the combined effect of Tanreqing injection and Imipenem is most synergistic and additive effect,the combined effect is better.
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