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Effect of Baofukang Suppository on proliferation and apoptosis in human cervical cancer cell SiHa

LI Qianjun;HU Yilin;LIANG Yan;WANG Ting;WU Xiaobin;CHAO Yan;The First Affiliated Hospital of Guangzhou Medical University;Shenzhen Maternity and Child Healthcare Hospital;The Second Affiliated Hospital of Guangzhou University of Chinese Medicine;  
Objective To investigate the effect of serum with Baofukang Suppository on proliferation and apoptosis of human cervical cancer cell SiHa at cellular level and to explore the possible mechanism of serum with Baofukang Suppository inhibiting the growth of SiHa.Methods Serum with Baofukang Suppository was applied to SiHa cells for 24 h,48 hand 72 h,and negative and serum with western medicine was set as control.By CCK8 and flow cytometry to study the effect of serum with Baofukang Suppository on proliferation,apoptosis and cell cycle of human cervical cancer cell SiHa.Results Serum with Baofukang Suppository suppressed the proliferation of cervical cancer cell SiHa,24 hhad the strongest inhibitory effect.The results of flow cytometry showed that cells in G0/G1 phase increased and S phase decreased in Baofukang Suppository group,which was significantly different from that in the negative control group(P0.05).Conclusion Baofukang Suppository may inhibit tumor growth by inhibiting the proliferation of cervical cancer cell SiHa and blocking the cell differentiation from G0/G1 phase to S phase and inducing apoptosis.
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