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Correlation between the expression of Survivin and Ki67 in uterus epithelium and apoptosis in patients with endometriosis

SHANG li;DU Erqiu;LI Yongmei;JI Daohua;LI Bin;Renmin Hospital,Hubei University of Medical;Hujiaying Township Hospital,Yuyang District,Shiyan,Hubei;Hubei Medical College;  
Objective To investigate the correlation between the expression of Survivin and Ki67 in uterus epithelium and apoptosis in patients with endometriosis(EMS).Methods From September 2013 to February2017,60 EMS patients for gynecological surgery and postoperative pathology confirmed in our hospital were selected as the observation group,and the other 60 patients of uterine fibroids(excluded EMS)were selected for surgical treatment were selected as the control group,used the immunohistochemical method to detect uterus epithelium Survivin and Ki67 expression,and were to determine the number of apoptotic cells and apoptotic index.Results The positive rates of Survivin and Ki67 in the uterus epithelium were 83.3%and 96.7%in the observation group,so that were 56.7%and 40.0%in the control group respectively,and the observation group were higher than in the control group(P0.05).The apoptotic index in the proliferative phase and secretory phase in the observation group were(11.42±2.91)%and(40.29±1.49)%,respectively.the control group were(31.45±2.41)%and(112.34±3.10)%,respectively,and the observation group were lower than that of the control group(P0.05).Pearson correlation analysis showed that the positive rates of Survivin and Ki67 in the uterus epithelium in observation group were showed obvious negative correlation to the proliferative phase and secretory phase apoptosis index(P0.05);the positive rate of Survivin was showed positive correlation to the Ki67 positive rate(r=0.672,P=0.000).Conclusion EMS patients with uterine epithelial Survivin and Ki67 are showed increased expression,and the proliferative phase and the secretory phase of the cell apoptosis index are significantly decreased,the expression of Ki67 and Survivin may be the mechanisms that lead to cell apoptosis index decreased.
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