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Metabonomic studies on the serum of the patients with viral hepatitis B and Hepatocellular carcinoma

YANG Wentao;XIE Baogang;XU Yanmei;LIU Yalan;ZOU Shubing;Department of Organ Transplant,the Second Affiliated Hospital of Nanchang University;College of Pharmacy,Nanchang University;Department of Clinical Laboratory,the Second Affiliated Hospital of Nanchang University;Department of Hepatobiliary Surgery,the Second Affiliated Hospital of Nanchang University;  
Objective To explore the metabolite composition of the serum samples from the hepatitis,Hepatocellular carcinoma(HCC)patients and healthy controls.Methods The serum samples from 49 patients with HCC,29 hepatitis B patients with negative DNA,26 hepatitis B patients with positive DNA were collected as case group,and 46 healthy as control group.The small molecular metabolites were detected AvanceⅡ-600 MHz,and the characteristic metabolites were screened by cluster analysis.Results Compared with the control group,there were 12 metabolites have the significant differences in the DNA negative hepatitis group,and 15 metabolites in the DNA positive hepatitis group,21 metabolites in the HCC group.Among the metabolites with significant differences in HCC,phenyletic acid was increased and other metabolites were decreased.Fourteen metabolites have the significant differences between the DNA negative hepatitis group with DNA positive hepatitis group.Conclusion Nuclear magnetic resonance hydrogen spectroscopy(NMR)can effectively screen the serum metabolites with significant differences between hepatitis B and HCC patients,and has broad prospects in the further non-invasive diagnosis of HCC.
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