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Consistency analysacais of household portable coagulation detector

CAI Peipei;ZHANG Wei;ZHOU Lianqun;YAN Ruhong;ZHU Hongnan;Department of Clinical laboratory,Suzhou Hospital Affiliated to Nanjing Medical University;CAS Key Laboratory of Bio-medical Diagnostics,Suzhou Institute of Biomedical Engineering and Technology,Chinese Academy of Sciences;  
Objective Consistency analysis of a portable coagulation detector for household use with Parylene-C modified quartz crystal microbalance(P-QCM)chip was to be analysed.Methods With activated partial thromboplastin time(APTT)as the detection index,the whole blood and plasma were detected by a portable coagulation detector with P-QCM chip,and compared with the internationally recognized optical coagulation detector.Results In the same centrifugal plasma sample tested 10 times independently,the absorption frequency shift CV%and APTT CV% of P-QCM chip portable coagulation detector decreased by 2.58%and1.24%,separately.Compared with the clinical measurement of Sysmex CS 2000 i,the clinical determination coefficient(R2)of 10 healthy blood samples was 0.983.Seven whole blood tests showed that the CV% of PQCM chip portable coagulation detector was 1.15%.Conclusion P-QCM household portable detector had stability and reproducibility of APTT measurements.It had the ability of clinical detection and could be used for whole blood test.Besides,it could be used as point of care testing.
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