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Clinical significance of serum NT-proBNP and soluble ST2 changes in patients with heart failure

DU Kun;ZHANG Mengqing;DENG Lin;ZHANG Guanghui;Department of Laboratory Medicine,Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine;  
Objective To investigate N-terminal B-type natriuretic peptide and soluble suppression of tumorigenicity(sST2)levels in inpatients with chronic heart failure.Methods The serum concentrations of NTproBNP and sST2 in 202 hospitalized patients with chronic heart failure were analyzed.The correlation between the two biomarkers and NYHA functional classifications was analyzed and the differences in the two biomarkers between the two groups were analyzed.Results The levels of NT-proBNP(P0.001)and sST2(P=0.002)were significantly different between the two groups.The levels of NT-proBNP and sST2 gradually increased with the increase of NYHA classification.Low-risk group and high-risk group also showed statistically significant differences in smoking history,LVEF,eGFR.Spearman correlation analysis showed that there was a positive correlation between NT-proBNP and sST2 level(r=0.247,P0.013).Spearman correlation analysis showed that sST2 was positively correlated with NYHA,and correlated negatively with LVEF.NT-proBNP was positively correlated with NYHA classification,negatively correlated with LVEF and eGFR.ROC curve analys showed that the area under the curve(AUC)of low-risk group and high-risk group with NT-proBNP and sST2 were 0.824 and 0.701,respectively.Compared with NT-proBNP,sST2 had no obvious advantage in the assessment of cardiac function in patients with chronic heart failure.The combined AUCarea of the two biomarkers was 0.872,with a sensitivity and specificity of 0.761 and 0.933 respectively.Conclusion sST2 levels were positively correlated with NT-proBNP and sST2 is superior to NT-proBNP in the diagnosis of patients with heart failure who have renal dysfunction simutaneously,sST2 combined with NT-proBNP was helpful in improving heart function grading assessment in patients with heart failure.which was a good supplement of NT-proBNP.
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