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Relationship between serum cystatin C jevel and coronary heart disease

LIU Yuwei;FENG Xiaomin;SU Jingjing;WAN Nan;Postgraduate Training Base,the General Hospital of Shenyang Military Region Dalian,Medical University;Laboratory of The General Hospital of Shenyang,Military;  
Objective To investigate the correlation between serum cystatin C(Cys C)and the diagnosis of coronary heart disease and coronary artery stenosis degree.Methods A total of 340 patients with coronary angiography were enrolled in this study.They were divided into non-coronary heart disease group(37 cases)and coronary heart disease group(303 cases).Coronary heart disease group includes 134 patients with angina pectoris,82 patients with acute non-ST elevation myocardial infarction,87 patients with acute ST segment elevation myocardial infarction.Detection of serum Cys C levels at admission and on the second day after coronary angiography or percutaneous coronary intervention(PCI),and the relationship between Cys C and the diagnosis of coronary heart disease and coronary artery stenosis degree were analyzed statistically.Results The Cys C level in patients with coronary heart disease(0.72±0.22)mg/L was significantly higher than that in noncoronary heart disease patients[(0.56±0.07)mg/L,P0.05].Area under ROC curve was 0.784 in diagnosis of coronary heart disease by serum Cys C,which showed specificity and sensitivity in diagnosis respectively as70.32%and 78.38%.There was no significant difference in Cys C levels between the groups with coronary heart disease.Cys C levels in single-vessel disease(0.63±0.21)mg/L were significantly lower than those in bi-and multi-vessel disease[(0.72±0.22)mg/L,(0.75±0.21)mg/L,P0.05],and the Cys C level was positively correlated with the number of lesions,and the correlation coefficient was 0.227,P0.05.Cys C levels were elevated in patients with percutaneous coronary intervention,but there was no significant change in patients with coronary angiography alone.Conclusion Cys C is still insufficient as a diagnostic indicator of coronary heart disease,but it is closely related to the severity of coronary artery disease,and may be related to inflammatory reaction after PCI.It can be used to assist in assessing the condition and postoperative detection.
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