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Analysis of the clinical value of anti MPO,anti GBM,anti PR3 and anti Ku antibody in autoimmune hemolytic anemia

DU Hanfang;XU Haijun;ZHAO Ying;Department of Clinical Laboratory,Shiyan Taihe Hospital;Department of Cardiology,Shiyan Taihe Hospital;  
Objective To explore the clinical value of serum anti myeloperoxidase(MPO)antibody,antiglomerular basement membrane(GBM)antibody,anti-proteinase 3(PR3)antibody and anti Ku antibody in autoimmune hemolytic anemia(AIHA).Methods 133 cases of AIHA patients admitted to a hospital from February 2015 to August 2017 were collected.In the same period,55 cases with other autoimmune diseases(22 cases of systemic lupus erythematosus,13 cases of rheumatoid arthritis,10 cases of autoimmune thyroid disease,4 cases of scleroderma and 6 cases of other diseases)and 106 healthy controls were collected.The four kinds of antibodies were detected by immunoblotting.Results Compared with healthy control group and other autoimmune diseases group,the numbers of positive anti MPO,anti GBM and anti PR3 were significantly increased in the patients with primary AIHA group and secondary AIHA group(P0.05).Compared with primary AIHA,the number of positive anti GBM in the secondary AIHA group was significantly increased(P0.05).The sensitivity of anti MPO antibody,anti GBM antibody and anti PR3 antibody for differential diagnosis of AIHA was 74.4%,45.1%,82.0%,respectively,and the specificity was 93.3%,95.3%,92.5%,respectively.There was no significant difference in the number of anti Ku antibody among the four groups(P0.05).Multinomial logistic regression results showed that after adjusting for age,sex,smoking and drinking,serum anti MPO,anti GBM and anti PR3 antibodies were still associated with the occurrence of AIHA.Conclusion The anti MPO,anti GBM and anti PR3 antibodies of serum may be a potential marker for the diagnosis of AIHA.
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