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Meta-analysis of the diagnostic value of miRNA-21 and miRNA-101 expression levels in colorectal cancer

CHU Huaizhu;HAN Nahui;LU Haidong;CAO Hongtao;XU Jianguo;Department of Oncology Surgery,Qinghai People′s Hospital;Department of Pain,Qinghai People′s Hospital;  
Objective To investigate the diagnostic value of microRNA-21(miRNA-21)and miRNA-101 expression levels in colorectal cancer.Methods The databases of PubMed,EMBASE,Cochranelibrary,VIP Chinese Journal Service Platform(VIP),Chinese Biomedical Journal Literature Database(CMCC),China Knowledge Network(CNKI)were searched,and miRNA-21 and miRNA-101 were collected in 2008-2018.Expression level diagnosis of colorectal cancer;Meta-analysis of data using Revman 5.3 and Meta-Disc 1.4 software,comprehensive evaluation of miRNA-21 by statistical indicators such as forest map and receiver operating characteristic curve(SROC curve)And the diagnostic value of miRNA-101 expression levels for colorectal cancer.Results A total of 534 articles were collected and 11 articles were included in the literature.The sample size was 1 040 cases,including 600 cases in the case group and 440 cases in the control group.The inclusion studies were heterogeneous.The randomized effect model,miRNA-21 and miRNA-101 expression levels were used to diagnose colorectal cancer with a combined sensitivity of 0.77,apooled specificity of 0.73,and apositive likelihood ratio of 2.97[95% confidence interval(95%CI):2.13 to 4.13],the negative likelihood ratio was 0.23(95%CI:0.10-0.56),the diagnostic odds ratio was 14.05(95%CI:6.39-30.91),and the area under the SROC curve(AUC)was 0.853 4.The sensitivity of miRNA-21 expression level for diagnosis of colorectal cancer was 0.64,the combined specificity was 0.75,the positive likelihood ratio was 2.97(95%CI:1.95-5.54),and the negative likelihood ratio was 0.26(95%CI:0.09-0.78).),the diagnostic odds ratio was 12.77(95%CI:4.60-35.43),AUCwas 0.855 9;the sensitivity of miRNA-101 expression level for colorectal cancer was 0.88,the combined specificity was 0.69,and the positive likelihood ratio was 2.80(95%CI:1.74-4.50),the negative likelihood ratio was 0.20(95%CI:0.11-0.36),the diagnostic odds ratio was15.56(95%CI:5.39-44.93),and the AUC was 0.8791.Conclusion The expression levels of miRNA-21 and miRNA-101 have certain reference value for the diagnosis of colorectal cancer.
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