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Application of combined detection of multiple serum tumor markers in the diagnosis of lung cancer

DU Hanfang;XU Haijun;LIN Li;Department of Clinical Laboratory,Shiyan Taihe Hospital;Department of Cardiology Ⅱ,Shiyan Taihe Hospital;  
Objective To investigate the clinical value of combined detection of CEA,CYFRA21-1,SCCAg,Pro-GRP and NSE in the diagnosis and treatment of lung cancer.Methods 120 patients with lung cancer and 40 patients with benignant lung diseases,which are received and cured in a hospital from December,2015 to October,2017.At the same time,40 healthy people were recruited when they were undergoing healthy examination as the control group.Then we detected and compared the levels of CEA,CYFRA21-1,SCC-Ag,ProGRP and NSE in the blood with electrochemiluminescence immunoassay respectively.Results The levels of CEA,CYFRA21-1,SCC-Ag,Pro-GRP and NSE in the lung cancer group were higher than that in the benignant lung disease group and control group,and the difference reached statistical significance(P0.05).The sensitivity values of CEA,CYFRA21-1,SCC-Ag,Pro-GRP and NSE were 9.2%,74.2%,42.5%,55.0%,20.8%,and the sensitivity of combined determination containing CEA,CYFRA21-1,SCC-Ag,Pro-GRP and NSE was 97.5%.Conclusion The joint detection of CEA,CYFRA21-1,SCC-Ag,Pro-GRP and NSE can improve the relevance ratio of lung cancer and it has important value in the diagnosis of lung cancer.
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