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The clinical valve of PCT,IL-6 and NLR in the diagnosis of chronic obstructive pulmonary disease acute exacerbation

WANG Xiuwei;YU Guoqing;Department of Clinical Laboratory,Wuhu Second People′s Hospital;Department of Clinical Laboratory,Wuhu Conch Hospital;  
Objective To investigate the value of procalcitonin(PCT),interleukin-6(IL-6)and neutrophillymphocyte ratio(NLR)in the diagnosis of chronic obstructive pulmonary disease acute exacerbation(AECOPD),analyze the correlation between PCT and other indicators of infection.Methods From January to June2016,106 patients with AECOPD were selected as the acute exacerbation group,37 patients with stable COPD were selected as the stable group,37 healthy subjects were selected as the control group.PCT,IL-6,NLR were detected in each group and the results were analyzed by statistical method.Results The levels of PCT、IL-6、NLR in the AECOPD group were significantly higher than those in the control group or stable COPD group(P0.05).Correlation analysis suggested that IL-6 was positively correlated with PCT(r=0.397,P0.05)and NLR was positively correlated with PCT(r=0.293,P0.05)in the AECOPD group.The area under ROC curve of PCT,IL-6 and NLR for COPD diagnosis was 0.905,0.758 and 0.818 respectively.Conclusion The levels of PCT,IL-6 and NLR in patients with AECOPD increased significantly,and there is a certain correlation between the indicators,which has certain clinical reference value in the diagnosis of AECOPD.
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