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Research progress of LncRNA in early diagnosis of gastric cancer

ZOU Lei;XIE Wanlin;ZHANG Xin;SUN Yihua;Department of Clinical Laboratory,Harbin Medical University Cancer Hospital;Department of Clinical Laboratory,The Second Affiliated Hospital of Harbin Medical University;  
Gastric cancer is a malignant tumor originating from gastric mucosal epithelial cells and ranks first in the incidence of various malignant tumors in China.Long non-coding RNA(lncRNA)is one of the most popular non-coding RNAs in cancer research.The role of LncRNA in gastric cancer has also been extensively studied,and lncRNA is an important component of tumor biology.In addition,studies have shown that lncRNA expression is abnormal in gastric cancer patients compared with healthy individuals.Based on the traditional detection methods of gastric cancer(endoscopic and pathological examination and serum biomarker determination),studies have shown that lncRNA can also be used for the diagnosis of gastric cancer,with high sensitivity,high specificity,non-invasiveness and low cost.Its combined diagnosis with conventional tumor markers is more accurate and can be used as an ideal biomarker for the detection of early gastric cancer.This article briefly describes the research progress of lncRNA in gastric cancer.
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