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Research progress on immunological pathogenesis of neuromyelitis optica

XIE Yuping;LU Pingxia;CAO Yingping;Department of Clinical Laboratory,Union Hospital of Fujian Medical University;  
Recently,researchers have begun to pay attention to the study of neuromyelitis optica(NMO)due to the discovery of the specific antibody-anti-aquaporin antibodies.With the deepening of research,understanding of the pathogenesis of NMO is increasing.It is believed that the pathogenesis of NMO is the consequence of the combined effect of genes,immune mechanisms and environment.Among them,the immune system is the most impotant role.The immune system is a large complex network,The coordination of which is the key to maintaining the homeostasis of body.And the destruction of any link might break the balance of immune system.In the present review,we will summarize the research progress of immunological pathogenesis of NMO from the perspective of antibody,complement and immune cells.
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