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《International Journal of Laboratory Medicine》 2019-10
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Association study on IL-8 gene rs4073 locus and hyperuricemia in males in Xinjiang Uygur

ZHANG Bei;LU Ying;MAYINA·Kahaer;DILIDAER·Kudereti;TIAN Ge;SONG Ruirui;ZHANG Xiaobo;YANG Shanshan;SUN Yuping;School of Basic Medicine,Xinjiang Medical University;First Affiliated Hospital,Xinjiang Medical University;Affiliated Chinese Medicine Hospital/Xinjiang Key Laboratory of Respiratory Diseases,Xinjiang Medical University;Graduate School,Xinjiang Medical University;Fifth Affiliated Hospital,Xinjiang Medical University;  
Objective To investigate the association between the polymorphism of interleukin-8(IL-8)gene and hyperuricemia in Xinjiang Uygurs.Methods A total of 1 168 Uyghur males,who took physical examination in the First Affiliated Hospital of Xinjiang Medical University,the First Peoples′Hospital of Kashgar,Turpan Hospital and Toli County People′s Hospital aged 20-60 years were selected as the study subjects in the minority residential areas.There were 594 cases in the control group and 574 cases in the hyeruricemia group.General physical examinations,uric acid and indicators related with renal function were detected.Taqman probe was used to detect IL-8 gene polymorphisms.The hyperuricemia group had fasting serum uric acid exceeding 417μmol/L.Results The frequency of genotype distribution and the distribution of allele frequency of rs4073 in IL-8 gene between the hyperuricemia group and the control group were statistically significantly different(P0.05).The risk of hyperuricemia of variant gene in IL-8 gene rs4073 was 1.61 times greater than that of the wild-type gene.Conclusion There is an increased risk of hyperuricemia among people with TT gene in IL-8 gene rs4073 locus.
【Fund】: 国家自然科学基金项目(81760169、81560153);; 新疆维吾尔自治区自然科学基金项目(2017D01C234 2019D01C218);; 上海市第六人民医院/上海市糖尿病重点实验室开放课题(SHKLD-KF-1502)
【CateGory Index】: R589.7;R440
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