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《International Journal of Laboratory Medicine》 2019-10
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Analysis of drug resistance of carbapenem-resistent Enterobacteriaceae in Chongqing from 2013 to 2016

WANG Zhu;SUN Shan;Department of Clinical Laboratory,the First Affiliated Hospital,Chongqing Medical University;  
Objective To investigate the distribution and antibiotic resistance of carbapenem-resistant Enterobacteriaceae(CRE)isolated in Chongqing from 2013 to 2016,in order to provide the basis for the clinical treatment.Methods A total of 4 694 clinical strains of CRE were collected from 2013 to 2016 in Chongqing.Antimicrobial susceptibility testing was performed with Kirby-Bauer or minimum inhibitory concentration method.The results were analyzed according to CLSI 2016 breakpoints.Results During 2013-2016,totally159 800 strains of Enterobacteriaceae were separated,among which,4 694 strains were CRE,accounting for2.9%.The detection rate of CRE was increasing year by year,and the top three of CRE was Klebsiella pneumoniae(1 748 strains accounting for 37.2%),Escherichia coli(1 261 strains accounting for 25.9%)and Enterobacter cloacae(891 strains accounting for 19.0%).The 4 694 strains of CRE were mainly separated from respiratory tract(2 521 strains accounting for 53.7%),followed by urine(798 strains accounting for 17.0%)and blood(282 strains accounting for 5.7%).Drug sensitivity test results showed that the resistance rate of CRE to amikacin was the least,accounting for 23.2%,followed by compound sulfamethoxazole,ciprofloxacin and gentamicin were 55.4%,55.5% and 56.3%,the resistant rates to other antibiotics were almost more than60.0%.Conclusion The detection rate of CRE in Chongqing is low,but there is also increased slowly,which should cause enough attention in clinic.Therefore the support of resistance detection of regional bacteria should be enhanced to provide useful information for the clinical treatment.
【Fund】: 重庆市卫生和计划生育委员会课题资助项目(2017MSXM009)
【CateGory Index】: R446.5
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