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《International Journal of Laboratory Medicine》 2019-10
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Correlation research of Opticin protein expression and retinopathy in serum of type 2 diabetic patients

SHAO Na;ZHANG Han;FENG Jie;Department of Ophthalmology,Jining No.1 People′s Hospital;Department of Ophthalmology,the Second Hospital of Shandong University;  
Objective To explore the relationship between the expression of Opticin protein and diabetic retinopathy(DR)in serum of type 2 diabetic patients.Methods From January 2015 to January 2017,120 type2 diabetic patients received in department of ophthalmology Jining No.1 Peopel′s hospital,were selected as research subject.According to the results directly after the glasses,or fundus photography,fundus fluorescein angiography,the patients were divided into diabetic patients without retinopathy(NDR group),non proliferative diabetic retinopathy(NPDR group)and proliferative diabetic retinopathy(PDR group),40 cases in each group.The levels of high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDLC),total cholesterol(TC)and triacylglycerol(TG)in the three groups were compared,the expression of Opticin protein in the serum of patients was detected by immunohistochemical method,and the changes of vision after 1 year in the three groups were also observed.Results There was no statistically significant difference in HDL-C,LDL-C,TC and TG levels among the three groups(P0.05).The levels of serum creatinine(Scr),urea nitrogen(UN)and estimated glomerular filtration rate(eGFR)among the three groups had statistically significant difference(P0.05);the PDR group had the lowest level of Scr and UN,the highest level of eGFR.The difference of serum Opticin protein expression between the three groups was statistically significant(P0.05).The serum Opticin protein level in PDR group was obviously lower than that in the NDR group and NPDR group with statistically significant difference(P0.05).There was a negative correlation between serum Opticin protein level and DR,Scr and UN(r=-0.311,-0.357,-0.029,P0.05),and positively correlated with glomerular filtration rate(r=0.302,P0.05).The decrease of serum Opticin protein and the decrease of eGFR level were independent risk factors for DR(P0.05).After 1 years of follow-up,the decrease rate of visual acuity in group PDR was higher than that in NDR group and NPDR group with statistically significant difference(P0.05).Conclusion Serum Opticin protein in the patients with diabetes is in lower expression,with the severity of retinopathy decreased gradually,as the independent risk factors of diabetic retinopathy,and Opticin protein,which could be one of the indicators of patients with diabetic retinopathy after assessment,is associated with the prognosis of the patients.
【Fund】: 济宁市科技发展计划(济科字【2016】56号-31)
【CateGory Index】: R587.2;R774.1;R446.6
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